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Following oral administration of a 200-mg dose in adults or a 10-mg/kg dose in febrile children, peak plasma concentrations and plasma concentration-time curves AUCs of ibuprofen appear to be increased in children compared with those achieved in adults; these differences appear to result from age- or fever-related changes in the volume of distribution in children and also to the variability of doses based on body weight administered to pediatric patients.

Peak plasma or serum ibuprofen concentrations of about 40-55 mcg/mL occur after about 1-1. Sources and Types of Discrepancies Between Electronic ... In people who already have heart failure, the chance of heart attack, having to go to the hospital for heart failure, and death is raised.

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