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Clinical data
Trade namesEvista, Optruma, others
License dataEU  EMA:  by INN, US   FDA: Evista
Pregnancy categoryAU: X (High risk) US: X (Contraindicated)
Routes of administrationBy mouth
Drug classSelective estrogen receptor modulator
ATC codeG03XC01 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Bioavailability2.0% [1]
Protein binding>95% [1]
MetabolismLiver, intestines (glucuro- nidation); [1] [2] CYP450 system not involved [1]
Elimination half-life27.7 hours [1]
ExcretionFeces [1]

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Raloxifene osteoporosis mechanism

The paternal incidence rates of cardiovascular breast cancer were raloxifene hydrochloride 4. and tamoxifen 4. per 1000 infants per year. ...